1To get tired or exhausted; to become weary (physically or mentally) after prolonged activity.
今日は一日中歩き回って、くたびれてしまった。
I walked around all day and got exhausted.
長時間の会議でみんなくたびれていた。
Everyone was worn out from the long meeting.
年末の仕事でくたびれて、休みが待ち遠しい。
I'm worn out from year-end work and looking forward to the holiday.
2To become worn out or shabby from long use; to show signs of wear.
そのコートは何年も着ていて、だいぶくたびれている。
That coat has been worn for years and is pretty shabby.
家具がくたびれてきたので、買い替えを検討している。
The furniture is getting worn out, so I'm thinking of replacing it.
3To grow tired or fed up with (doing something or with something); to become weary of it.
同じ説明を何度も聞かされて、くたびれてしまった。
I was made to hear the same explanation over and over and got fed up.
彼の自慢話にはもうくたびれたよ。
I'm tired of his boasting already.