In itself; by itself — referring to the intrinsic nature or value of something, independent of other factors.
その考えそれ自体は間違っていないが、実行は難しい。
The idea itself isn't wrong, but it's difficult to implement.
この装置それ自体には問題はないが、使い方に注意が必要だ。
The device itself has no problems, but you need to be careful how you use it.
その本それ自体は面白いが、翻訳の質が気になる。
The book itself is interesting, but I'm concerned about the quality of the translation.