By all means; no matter what — expresses a strong determination to do or achieve something regardless of obstacles.
何が何でも合格して、大学に行きたい。
I want to pass no matter what and go to university.
彼は何が何でも約束を守ると誓った。
He swore he would keep his promise at all costs.
今月中に何が何でもこのプロジェクトを終わらせる。
I'll finish this project within the month no matter what.