Anything and everything; just about everything—used to emphasize the entirety of things (often appears with negative or emotional contexts).
何もかも忘れて旅に出たい。
I want to forget everything and go on a trip.
彼は何もかも私のせいだと言った。
He said I was to blame for everything.
何もかもがうまくいっている。
Everything is going well.
母は何もかも心配してしまう性格だ。
My mother is the kind of person who worries about everything.