An expression meaning 'hopeless' or 'there's nothing that can be done,' describing a situation that cannot be fixed or salvaged.
今回のミスは大きくて、どうにもならない気がする。
This mistake is so big that I feel it's beyond help.
壊れた機械は修理できず、どうにもならないと言われた。
They told me the broken machine couldn't be repaired and was hopeless.
もう時間が足りない。今回はどうにもならないかもしれない。
There isn't enough time. This time it might be hopeless.