A state of looking thin, tired, or worn out; emaciation or haggardness (used as a noun).
入院してから彼のやつれが目立つようになった。
Since being hospitalized, his emaciation has become noticeable.
長時間の出張でやつれが取れない。
After the long business trip, I still can't shake off the haggard look.
彼女のやつれた顔を見ると心配になる。
Seeing her haggard face makes me worried.