Rest or relief for the body or mind; somewhat literary, implying recuperation or relaxation.
登山の後は十分な休息が必要だ。
You need plenty of rest after climbing a mountain.
出張が続いたので、週末は休息に当てた。
Because I had consecutive business trips, I spent the weekend resting.
医師に休息を勧められた。
The doctor recommended rest.