1The act of losing money or something valuable, or suffering damage; also describes something as unprofitable.
投資に失敗して、かなりの損を出してしまった。
My investment failed and I ended up with a considerable loss.
セール品を買ったのに使わなかったら損だ。
If you buy something on sale and never use it, that's a waste of money.
台風で農作物に大きな損が出た。
The typhoon caused major damage to the crops.
今やめたら、これまでの努力が損になる。
If I quit now, all my effort so far will have been for nothing.
2Being at a disadvantage as a result of some action, or a situation that puts one at an unfavorable position.
正直すぎる性格は、時に損をすることがある。
Being too honest can sometimes put you at a disadvantage.
早く言えば得なのに、黙っていたせいで損な立場になった。
Speaking up early would have helped, but staying silent put him at a disadvantage.
内気な性格は面接では損になることがある。
A shy personality can be a handicap in job interviews.