Loss, damage, or harm; something unprofitable or causing a deficit (often used in expressions like 'to suffer a loss').
保険があるから大きな損はしないだろう。
Because we have insurance, we probably won't suffer a large loss.
あのミスで会社に多額の損が出た。
That mistake caused the company a substantial loss.
小さな損を気にしすぎると、かえって不利になることもある。
If you worry too much about small losses, it can actually put you at a disadvantage.
A disadvantage, handicap, or drawback; an unfavorable aspect of a situation (used as 'a loss' or 'to be at a disadvantage').
この契約だと顧客にとって損になる条項がある。
This contract contains clauses that would be disadvantageous for customers.
彼にとってその提案は損だと判断した。
He judged that the proposal would be disadvantageous for him.
短期的には損をしても、長期的には得になることがある。
Even if you take a short-term loss, it can sometimes pay off in the long run.