Weariness; fatigue; exhaustion. Refers to the state of being tired and is also used as a suffix meaning 'tired from' (e.g., 遊び疲れ, 湯疲れ).
長旅の疲れがまだ取れない。
I still can't shake off the fatigue from the long trip.
遊び疲れで子どもはすぐに寝てしまった。
The child was so tired from playing that they quickly fell asleep.
熱い湯に長く入った後の湯疲れに注意してください。
Be careful of exhaustion from soaking too long in hot water.