1To put clothes on another person (or an animal, doll, etc.) - dressing someone rather than oneself.
母は毎朝、幼い息子に服を着せている。
Every morning, the mother dresses her young son.
寒い日は犬にも小さな服を着せる。
On cold days, I put a little outfit on the dog too.
人形にきれいなドレスを着せて飾った。
I dressed the doll in a pretty dress and displayed it.
入院中の祖母に新しいパジャマを着せてあげた。
I put new pajamas on my grandmother while she was in the hospital.
2To cover, coat, or plate the surface of an object with a layer of some material.
安いアクセサリーに金メッキを着せて売っている店がある。
There are shops that gold-plate cheap accessories and sell them.
古い椅子に新しい布を被せて張り替えた。
I re-covered the old chair with new fabric.
木材の表面にニスを着せて艶を出した。
I applied varnish to the wood surface to give it a shine.
3To force blame or a crime someone didn't actually commit onto them; commonly used as 罪を着せる / 濡れ衣を着せる ('to frame someone').
同僚は自分のミスを彼に着せようとした。
A coworker tried to pin his own mistake on him.
無実の男に濡れ衣を着せた事件が明らかになった。
A case in which an innocent man was framed came to light.
そんな悪評を着せられるのは心外だ。
It's upsetting to have such a bad reputation pinned on me.