To abandon or give up on someone or something; to desert or stop supporting/expecting someone.
病気になっても家族が彼を見放すことはなかった。
Even when he fell ill, his family did not abandon him.
困っている人を見放してはいけない。
You must not give up on people in trouble.
チームはファンに見放され、成績が落ちた。
The team was abandoned by its fans and its performance declined.