1To give up on a hope, plan, or effort and decide not to pursue it any further; often carries the nuance of accepting the outcome as unavoidable.
何度失敗しても、彼は最後まで諦めなかった。
No matter how many times he failed, he never gave up until the end.
彼は医者になる夢を諦めて、家業を継ぐことにした。
He gave up his dream of becoming a doctor and decided to take over the family business.
今日中に終わらせるのは諦めて、明日また続けよう。
Let's give up on finishing it today and pick it up again tomorrow.
医者に病状を説明されても、彼女はまだ諦めきれずにいた。
Even after the doctor explained her condition, she still couldn't bring herself to give up.