To pierce or penetrate (to go through something), e.g. an arrow or bullet piercing an object.
矢が鎧を貫いた。
The arrow pierced the armor.
光が窓ガラスを貫いて室内を照らした。
Light passed through the window glass and lit the room.
銃弾は車のボンネットを貫いた。
A bullet went through the car's hood.
To run through or pass through (e.g., a road, river, or tunnel running through a place).
幹線道路が市街地を貫いている。
The main road runs through the city area.
鉄道トンネルが山を貫く予定だ。
The railway tunnel is planned to run through the mountain.
川が町を貫いて流れている。
A river flows through the town.
To stick to or carry out (a belief, principle, or policy) to the end; to persist in maintaining something.
彼は信念を貫いて会社を辞めた。
He resigned from the company, sticking to his convictions.
約束を貫くために全力を尽くした。
I did my best to keep my promise.
教師は教育の理念を貫いて教壇に立っている。
The teacher stands at the podium adhering to their educational principles.