To go against, oppose, disobey, or defy someone or something (an opinion, order, current, etc.).
子どもが親の意見に逆らうこともある。
Children sometimes go against their parents' opinions.
上司の命令に逆らってプロジェクトを中止した。
He defied his boss's orders and stopped the project.
自然の法則に逆らうことはできない。
You cannot go against the laws of nature.