To be harmful to or to interfere with; to have a detrimental effect or cause trouble (often used as '〜に障る').
夜更かしは健康に障るから控えたほうがいい。
Staying up late is bad for your health, so you should avoid it.
彼の不用意な発言がプロジェクトの進行に障った。
His careless remark interfered with the progress of the project.
強い香水は隣の人の鼻に障るかもしれない。
A strong perfume might irritate the person next to you.