alcohol; (esp.) sake — a polite term for alcoholic beverages. Adding 'お' makes it a courteous expression.
お酒はほどほどに飲んでください。
Please drink alcohol in moderation.
昨夜は友達とお酒を飲んだ。
I drank alcohol with friends last night.
お酒に強いほうですか？
Are you tolerant of alcohol? / Can you handle your alcohol well?
祝杯にお酒を一杯あげましょう。
Let's raise a glass of alcohol for the celebration.