To be able to bear or endure (something building up to an unbearable degree). Often appears in expressions like 'たまらない' (cannot bear).
こんな理不尽な扱いは胸に堪る。
This kind of unfair treatment weighs on me / is unbearable.
長時間の立ち仕事で足の疲れが堪まった。
After standing for a long time at work, the fatigue in my legs became intense.
彼の失礼な言葉がどうしても堪らない。
I simply can't tolerate his rude remarks.