1To manage, run, or take charge of something (often single-handedly); to oversee and control operations.
彼女が社内イベントの準備を取り仕切った。
She took charge of preparing the company event.
小さな店を一人で取り仕切るのは大変だ。
It's tough to run a small shop all by oneself.
プロジェクトを取り仕切るリーダーが必要だ。
We need a leader to take charge of the project.